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The kidney and hypertension

K Abe1, S Ito

  • 1Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|June 1, 1997
PubMed
Summary

The kidney plays a dual role in hypertension, acting as both a target organ and a cause. This review explores the kidney's complex involvement in hypertension, covering key physiological systems and treatments.

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Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Physiology

Background:

  • The kidney is a critical target organ in hypertension.
  • The kidney can also be a primary cause of hypertension.
  • Understanding the kidney's role is crucial for managing hypertension.

Purpose of the Study:

  • To review the multifaceted role of the kidney in the development and progression of hypertension.
  • To summarize research on the kidney's involvement in hypertension, including physiological systems and therapeutic approaches.

Main Methods:

  • Review of basic and clinical studies on the kidney and hypertension.
  • Analysis of the renin-angiotensin system, kallikrein-kinin system, and prostaglandin system.
  • Examination of glomerular hemodynamics, therapeutic strategies, and patient prognosis.

Main Results:

  • The kidney significantly influences blood pressure regulation through various systems.
  • Dysfunction in renal hemodynamics and hormonal systems contributes to hypertension.
  • Therapeutic interventions targeting the kidney show promise in managing hypertension.

Conclusions:

  • The kidney's complex role in hypertension necessitates a comprehensive understanding.
  • Further research into renal mechanisms is vital for improving hypertension treatment and outcomes.

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