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The kidney and hypertension
1Second Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan.
Insights
The kidney plays a dual role in hypertension, acting as both a target organ and a cause. This review explores the kidney's complex involvement in hypertension, covering key physiological systems and treatments.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Physiology
Background:
- The kidney is a critical target organ in hypertension.
- The kidney can also be a primary cause of hypertension.
- Understanding the kidney's role is crucial for managing hypertension.
Purpose of the Study:
- To review the multifaceted role of the kidney in the development and progression of hypertension.
- To summarize research on the kidney's involvement in hypertension, including physiological systems and therapeutic approaches.
Main Methods:
- Review of basic and clinical studies on the kidney and hypertension.
- Analysis of the renin-angiotensin system, kallikrein-kinin system, and prostaglandin system.
- Examination of glomerular hemodynamics, therapeutic strategies, and patient prognosis.
Main Results:
- The kidney significantly influences blood pressure regulation through various systems.
- Dysfunction in renal hemodynamics and hormonal systems contributes to hypertension.
- Therapeutic interventions targeting the kidney show promise in managing hypertension.
Conclusions:
- The kidney's complex role in hypertension necessitates a comprehensive understanding.
- Further research into renal mechanisms is vital for improving hypertension treatment and outcomes.
Abstract:
The kidney is important not only as a target organ of hypertension but also as a organ that may cause hypertension. For many years, we have studied basic and clinical aspects of the role of the kidney in hypertension, including the renin-angiotensin, kallikrein-kinin, and prostaglandin systems, glomerular hemodynamics, therapeutic modalities, and prognosis. This review summarizes some of our results together with those of other relevant studies in the literature.