[The effect of complete fasting on the structural-functional organization of the white pulp of the spleen]

The work presents the results of morphologic, electron microscopic and morphometric assessment of the liver in white mongrel rats in the dynamics of complete long fasting. The investigations reveal that 7 days complete fasting in animals is accompanied by a certain dynamics of structural-functional reconstruction in various zones of splenic white pulp. The periarterial area shows microlymphocytes number decrease (T-dependent zone). However, B-dependent area of splenic white pulp experiences more significant reducing lymphocytes. Via electron microscopic observation pit-cells ultrastructure (the tissue form of large containing granules lymphocytes possessing a natural killing activity) has been ascertained. It is of note that in the dynamics of complete fasting there occurs remarkable increasing a relative pit-cells quantity, these pit-cells containing osmophilic macrogranules, proving their sharp functional activity rise. Complete long fasting demonstrates sufficient immunosuppressive effect with simultaneous enhancing nonspecific resistance of the organism due to a greater amount of natural killers and ascending their functional activity.