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[Perineurioma]

M Zámecník1, P Gomolcák

  • 1Oddelenie patológie NsP, Trencín.

Ceskoslovenska Patologie
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Perineurioma, a rare benign tumor of perineurial cells, presented subcutaneously in a thigh. Immunohistochemistry, particularly epithelial membrane antigen (EMA) expression, is key for diagnosis.

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Area of Science:

  • Oncology
  • Surgical Pathology

Background:

  • Perineurioma is a rare, benign neoplasm originating from perineurial cells.
  • Distinguishing perineurioma from other soft tissue tumors is crucial for accurate diagnosis and management.

Observation:

  • A subcutaneous tumor in the right thigh of a 53-year-old male was analyzed.
  • The tumor exhibited well-limited borders and whorl-like/concentric laminar bundles of spindle and oval cells.
  • Focal meningioma-like structures were noted, characterized by cells with abundant cytoplasm, bland nuclei, and intranuclear pseudoinclusions.

Findings:

  • The presented tumor lacked a storiform pattern, a feature sometimes associated with perineurioma.
  • Immunohistochemical analysis revealed positive epithelial membrane antigen (EMA) expression and negative S-100 protein staining.

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  • Differential diagnosis included benign neuronal tumors, dermatofibrosarcoma protuberans, and fibromyxoid sarcoma.

    • Implications:

    • Accurate diagnosis of perineurioma relies on characteristic histopathological features and specific immunohistochemical markers.
    • EMA positivity and S-100 negativity are important indicators for identifying perineurioma.
    • This case highlights the importance of considering perineurioma in the differential diagnosis of subcutaneous soft tissue tumors.