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[Phospholipase A2--acute phase protein after liver surgery?]
F Gerhard1, H Treusch, G E Hofmann
1Klinik für Allgemeinchirurgie, Johann Wolfgang Goethe-Universität, Frankfurt am Main.
Zeitschrift Fur Gastroenterologie
|April 1, 1997
Summary
Phospholipase A2 levels remain unchanged after liver surgery, even with an acute phase response. This finding suggests that the liver may not be the primary source of phospholipase A2 during such events.
Area of Science:
- Biochemistry
- Surgical Research
- Immunology
Background:
- The precise origin of phospholipase A2 (PLA2) remains undetermined.
- The liver is a potential source, as PLA2 secretion may be triggered by acute phase responses.
Purpose of the Study:
- To investigate the source of phospholipase A2 (PLA2) by examining its levels in patients undergoing liver resection.
- To compare PLA2 levels in liver resection patients with control groups and septic patients.
Main Methods:
- Prospective study involving three patient groups: liver resection (n=12), control surgery (n=22), and sepsis (n=5).
- Blood samples collected preoperatively, daily for seven days postoperatively, and at discharge.
- Biochemical analysis included phospholipase A2, PMN-elastase, C-reactive protein, GPT, GOT, GLDH, and cholinesterase.
Main Results:
- Phospholipase A2 levels were unchanged postoperatively in liver resection and control groups.
- Septic patients showed a significant increase in phospholipase A2 levels.
- GPT, GOT, and GLDH levels increased post-liver resection; C-reactive protein elevated in all groups.
Conclusions:
- The stable phospholipase A2 levels after liver surgery, despite an acute phase response, do not support a hepatic origin.
- Further research is needed to elucidate the exact source of phospholipase A2 in the context of acute phase responses.