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Related Experiment Videos

Changes in the optic disc over a five-year interval: the Beaver Dam Eye Study

B E Klein1, R Klein, S C Jensen

  • 1Department of Ophthalmology and Visual Sciences, University of Wisconsin Medical School, Madison 53705-2397, USA.

Current Eye Research
|July 1, 1997
PubMed
Summary

Changes in intraocular pressure were linked to increased optic disc cupping in adults over five years. This suggests regular eye pressure monitoring may be important for older individuals.

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Area of Science:

  • Ophthalmology
  • Optometry
  • Glaucoma Research

Background:

  • Intraocular pressure (IOP) is a key risk factor for glaucoma.
  • Optic disc cupping is a clinical sign of glaucomatous damage.
  • Longitudinal studies are needed to understand the relationship between IOP changes and optic disc morphology.

Purpose of the Study:

  • To investigate the association between changes in intraocular pressure and vertical optic disc cupping over a five-year period.
  • To determine if IOP fluctuations correlate with structural changes in the optic nerve head.

Main Methods:

  • Utilized stereoscopic optic disc photographs from The Beaver Dam Eye Study cohort.
  • Quantified optic disc and cup dimensions and graded other disc features.
  • Measured intraocular pressure using Goldmann applanation tonometry at baseline and follow-up.

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Main Results:

  • A significant association was found between changes in intraocular pressure and the vertical cup-to-disc ratio.
  • No significant associations were observed between IOP change and incident disc hemorrhage, flattened temporal rim, notching, cup reaching disc margin, or undercutting.

Conclusions:

  • Elevated intraocular pressure changes are associated with increased optic disc cupping in an adult population.
  • These findings support the clinical practice of regular follow-up for older adults with fluctuating intraocular pressure.
  • Further research is warranted to confirm this relationship and its clinical implications.