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[Urinary catecholamine excretion in aging]

J Juchmès, L Pierquin, A Cession-Fossion

Archives Internationales De Physiologie Et De Biochimie

|February 1, 1979

Summary

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Ageing women show reduced urinary noradrenaline excretion (UNA) but increased UNA to creatinine clearance ratio, suggesting higher plasma noradrenaline levels. The physiological significance of these changes in ageing remains unclear.

Area of Science:

Gerontology
Neuroendocrinology
Urology

Context:

Ageing is associated with significant physiological changes.
Understanding neuroendocrine alterations in ageing is crucial for health.
Urinary markers can reflect systemic physiological states.

Purpose:

To investigate changes in urinary noradrenaline excretion (UNA) in ageing female subjects.
To assess the relationship between UNA, plasma noradrenaline, and creatinine clearance with ageing.
To explore the physiological implications of observed alterations.

Summary:

Ageing female subjects exhibit decreased urinary noradrenaline excretion (UNA) compared to young adults.
The ratio of UNA to endogenous creatinine clearance increases with age, indicating elevated plasma noradrenaline.

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The ratio of urinary adrenaline (UA) to creatinine clearance remains unchanged.

Impact:

These findings suggest a link between ageing and increased noradrenaline levels in plasma.
The study highlights potential biomarkers for ageing-related physiological shifts.
Further research is needed to elucidate the precise physiological meaning of these age-related changes.