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Colitis associated to chemotherapy with 5-fluorouracil
F Trevisani1, M Simoncini, G Alampi
1Department of Internal Medicine, University of Bologna, Italy.
Hepato-Gastroenterology
|May 1, 1997
Summary
Antitumoral agents like 5-fluorouracil can cause pseudomembranous colitis. This case highlights a rare instance of this condition developing during 5-fluorouracil monotherapy, successfully treated with vancomycin.
Area of Science:
- Gastroenterology
- Oncology
- Infectious Diseases
Background:
- Antitumoral agents, particularly in combination therapies, are known to induce pseudomembranous colitis due to their antimitotic and antibacterial effects.
- While 5-fluorouracil (5-FU) commonly causes nonspecific colitis or diarrhea, proven pseudomembranous colitis during monotherapy is exceptionally rare.