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Human erythrocyte polyamine levels after partial hepatectomy
T Tsukamoto1, H Kinoshita, K Hirohashi
1Second Department of Surgery, Osaka City University Medical School, Japan.
Hepato-Gastroenterology
|May 1, 1997
Summary
Erythrocyte polyamine levels, particularly spermidine, correlate with the extent of liver resection. These polyamine changes may serve as a useful indicator of liver regeneration status after partial hepatectomy.
Area of Science:
- Hepatology
- Biochemistry
- Surgical Research
Background:
- Clinically useful indices for monitoring liver regeneration are lacking.
- Polyamines are essential for cell growth and proliferation.
- Erythrocyte polyamine levels may offer insights into hepatic regeneration.
Purpose of the Study:
- To investigate the relationship between erythrocyte polyamine levels and the degree of liver regeneration after partial hepatectomy.
- To determine if erythrocyte polyamine levels can serve as a clinical marker for liver regeneration.
Main Methods:
- Assayed erythrocyte polyamine levels (putrescine, spermidine, spermine) using high-pressure liquid chromatography.
- Studied 91 patients post-partial hepatectomy, categorized by resection extent (≥20%, <20%, smaller operations).
- Included 13 control patients who underwent non-hepatectomy surgery.
Main Results:
- Erythrocyte spermidine and spermine levels increased post-surgery, peaking at 7-14 days, and then decreased.
- A significant correlation was observed between the proportion of liver resected and the percent increase in erythrocyte polyamines.
- Spermidine level differences among the resection groups were statistically significant.
Conclusions:
- Erythrocyte polyamine levels, especially spermidine, are associated with the extent of liver resection.
- These findings suggest erythrocyte polyamine levels could potentially reflect the degree of liver regeneration.