Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hepatic dysfunction following cardiac surgery: determinants and consequences

A Michalopoulos1, P Alivizatos, S Geroulanos

  • 1Onassis Cardiac Surgery Center, Athens, Greece. amichalopoulos@hol.gr

Hepato-Gastroenterology
|May 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The impact of age on quality of life and frailty outcomes after parathyroidectomy in patients with primary hyperparathyroidism.

Journal of endocrinological investigation·2021
Same author

Bowel intussusception in adults: a report of three interesting cases and current trends for diagnosis and surgical management.

Hippokratia·2020
Same author

Management of peritoneal hydatid cysts: A fourty-year experience.

Heliyon·2018
Same author

Anal canal gastrointestinal stromal tumors - report of a rare case and review of the literature.

Hippokratia·2018
Same author

Dermatofibrosarcoma protuberans: a case report and review of the literature.

Hippokratia·2016
Same author

The effect of intraoperative lavage with short chain fatty acids (SCFAs) on rectal anastomosis of rats receiving corticosteroids.

Hippokratia·2015

Postoperative hepatic dysfunction after cardiac surgery, affecting 3.2% of patients, is linked to increased morbidity and mortality. Key determinants include operative factors and patient characteristics, highlighting the critical role of hepatic blood flow and bilirubin levels.

Area of Science:

  • Cardiology
  • Hepatology
  • Critical Care Medicine

Background:

  • Hepatic dysfunction is a potential complication following cardiac surgery.
  • Understanding its determinants and consequences is crucial for patient outcomes.

Purpose of the Study:

  • To prospectively investigate the factors influencing hepatic dysfunction post-cardiac surgery.
  • To characterize the clinical features and outcomes of patients developing this complication.

Main Methods:

  • A cohort of 3041 adult patients undergoing open heart surgery was studied.
  • Hepatic dysfunction was defined as jaundice with serum bilirubin >3 mg/dl in the early postoperative period.
  • Patients were divided into those with and without hepatic dysfunction for comparison.

Related Experiment Videos

Main Results:

  • 3.2% of patients developed postoperative hepatic dysfunction.
  • Univariate analysis identified sex, NYHA class, surgery type, operative time, low cardiac output syndrome, cardiac arrest, hematomas, and blood transfusions as determinants.
  • Hepatic dysfunction was associated with prolonged ventilation, longer ICU/hospital stays, and significantly higher mortality (11.4%).

Conclusions:

  • The pathogenesis of hepatic dysfunction is multifactorial, with reduced perioperative hepatic flow and increased bilirubin load being critical.
  • Early postoperative hepatic dysfunction significantly increases patient morbidity and mortality after cardiac surgery.