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B cell development in mice

J F Kearney1, W J Won, C Benedict

  • 1Department of Microbiology, University of Alabama at Birmingham 35294, USA.

International Reviews of Immunology
|January 1, 1997
PubMed
Summary
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The B cell repertoire develops through genetic gene rearrangement and environmental antigen selection. This review explores how these forces shape the immune system from fetal life through adulthood, highlighting key differences between early and adult immune responses.

Area of Science:

  • Immunology
  • Molecular Biology
  • Developmental Biology

Background:

  • The B cell repertoire is crucial for adaptive immunity.
  • Its development involves complex genetic and environmental interactions.
  • Understanding these processes is key to comprehending immune system maturation.

Purpose of the Study:

  • To review the genetic and selective mechanisms shaping the B cell repertoire.
  • To elucidate the dynamic processes from fetal life to adulthood.
  • To highlight differences between the early and adult immune systems.

Main Methods:

  • Review of existing literature on immunoglobulin (Ig) gene rearrangement.
  • Analysis of somatic events like N segment addition and somatic mutation.
  • Examination of B cell selection by self and exogenous antigens (Ags).

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Main Results:

  • Genetic factors include Ig gene rearrangement, N segment addition, and somatic mutation.
  • Environmental factors involve positive and negative selection by antigens based on Ig receptor specificity.
  • These dynamic processes begin in fetal life and continue throughout life.

Conclusions:

  • B cell repertoire development is a continuous interplay of genetic and environmental influences.
  • Significant differences exist in the immune system's early stages compared to the adult.
  • The review provides insights into the mechanisms driving these developmental changes.