Related Experiment Video
Updated: Jul 1, 2026
Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 31, 2013
Prognostic value of Ki-67 for recurrence and progression of superficial bladder cancer
1Department of Urology, Yokohama City University School of Medicine, Japan.
Purpose:
We retrospectively reviewed 104 cases of superficial bladder cancer to ascertain whether the Ki-67 labeling index predicts recurrence and progression.
Materials And Methods:
Archival specimens from superficial bladder cancer cases were immunostained with Ki-67.
Results:
The recurrence rate was significantly higher in cases with a Ki-67 labeling index of 5.35 or greater than in those with a value less than 5.35 (p < 0.001). The recurrence rate at 2 years was 70% in cases with a Ki-67 labeling index of 5.35 or greater and 22% in those with an index less than 5.35 (p < 0.001). Using multivariate analysis the index predicted recurrence of bladder cancer (p < 0.005). Median Ki-67 labeling index in cases with progression was significantly higher than in those without progression (p < 0.01).
Conclusions:
The Ki-67 labeling index is an independent predictive factor for recurrence of superficial bladder cancer.
