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[Study of bone density in systemic scleroderma]

H C da Silva1, V L Szejnfeld, L S Assis

  • 1Universidade Federal de São Paulo, Escola Paulista de Medicina, São Paulo.

Revista Da Associacao Medica Brasileira (1992)
|January 1, 1997
PubMed
Summary

Systemic sclerosis patients do not exhibit generalized bone loss. This study indicates scleroderma is not a risk factor for osteoporosis, contrary to previous suggestions of osteopenia.

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Area of Science:

  • Rheumatology
  • Endocrinology
  • Bone Metabolism

Background:

  • Osteopenia has been reported in systemic sclerosis (scleroderma) patients, with theories suggesting chronic ischemia, immobilization, or early menopause as causes.
  • However, generalized osteopenia in these patients remains unconfirmed.
  • This study aimed to investigate bone mineral density across multiple skeletal sites in scleroderma patients.

Purpose of the Study:

  • To determine if patients with systemic sclerosis (scleroderma) experience generalized bone loss.
  • To assess bone mineral density in the spine, proximal femur, and total body of scleroderma patients.

Main Methods:

  • Twenty-five Caucasian women with systemic sclerosis were evaluated.
  • Bone mineral density was measured using dual-photon absorptiometry (Lunar-Model DPX).
  • Measurements included the spine, proximal femur, and total body.

Main Results:

  • Bone mass in scleroderma patients was not statistically different from age-matched healthy controls.
  • No significant difference in bone mass was observed between limited and diffuse forms of systemic sclerosis.
  • Patients with calcinosis showed lower bone mass at the proximal femur compared to those without calcinosis.

Conclusions:

  • Systemic sclerosis patients do not present with generalized bone loss.
  • Scleroderma is not identified as a risk factor for generalized osteoporosis.
  • Calcinosis may be associated with reduced bone mass at the proximal femur in scleroderma patients.

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