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Eosinophils and human cancer

M Samoszuk1

  • 1Pathology Department, University of California, Irvine 92697-4800, USA.

Histology and Histopathology
|July 1, 1997
PubMed
Summary

Eosinophils, typically linked to allergies and parasites, are frequently found in various human cancers. Their presence in tumors may influence tumor biology and host interactions, despite not significantly affecting patient prognosis.

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Area of Science:

  • Oncology
  • Immunology

Background:

  • Eosinophils are granulocytes associated with allergic diseases and parasitic infections.
  • Eosinophilia, an increase in eosinophils, is observed in various human cancers, both within tumors and in peripheral blood.

Purpose of the Study:

  • To investigate the presence and potential role of eosinophils in different types of human cancer.
  • To explore the implications of tumor-associated eosinophilia in cancer biology and host-tumor interactions.

Main Methods:

  • Utilized specialized techniques like autofluorescence and immunohistochemistry to detect eosinophils within tumor tissues.
  • Examined eosinophil presence in hematologic tumors (Hodgkin's disease, lymphomas) and solid tumors (colon, cervix, lung, breast, ovary).

Main Results:

  • Extensive eosinophilia is commonly found in hematologic malignancies and other cancers when specifically investigated.
  • The presence or absence of tumor-associated eosinophilia does not appear to significantly impact patient prognosis.

Conclusions:

  • Eosinophils may play a role in tumor-host interactions, potentially promoting angiogenesis and connective tissue formation.
  • Tumor-related eosinophilia offers insights into tumor biology, including cytokine production by cancer cells.

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