Related Experiment Video
Updated: Aug 6, 2026

Multi-electrode Array Recordings of Human Epileptic Postoperative Cortical Tissue
Published on: October 26, 2014
Polarization anatomy of a kainic acid seizure
1Department of Veterans Affairs, School of Medicine, Texas Tech University, Lubbock 79430, USA.
Abstract:
Slow voltage-sensitive dyes work by accumulating in brain tissue and report the average membrane potential of neurons and glia. The voltage-sensitive dye diO-C2-5 was used to monitor the polarization state of 27 brain structures in the rat during a systemically induced, behaviorally mild, kainic acid seizure using a 20 s recording period. The effects of the anesthetic agent used in the experiment were minimized by delaying the dye injection and seizure mapping for one day. Eleven areas were depolarized during the seizure, but 16 other areas did not change their polarization state compared to controls. The effects of pentobarbital appear to have no measurable effect on seizure propagation once the animal has behaviorally recovered from the anesthesia. The technique allows for mapping areas of seizure involvement with a unique combination of spatial and temporal resolution.
More Related Videos
06:28High-Quality Seizure-Like Activity from Acute Brain Slices Using a Complementary Metal-Oxide-Semiconductor High-Density Microelectrode Array System
Published on: September 27, 2024
07:35Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
Published on: July 8, 2025
Related Concept Videos
Action Potential: Phases of Stimulation
Resting Phase:
In this phase, the cell's membrane is at its resting potential, typically around -70 millivolts (mV) for neurons. Inside the cell, there is a higher concentration of potassium ions (K+) and a lower concentration of sodium ions (Na+). Voltage-gated sodium channels are closed, and...
Epilepsy and Seizures: Overview
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Seizures: Classification
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:
Seizures l: Introduction
Seizures ll: Types
Epilepsy ll: Types