Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Changes in vitamin E concentration after surgery and anesthesia

J Zunić1, A Stavljenić-Rukavina, P Granić

  • 1Department of Anesthesiology and Intensive Care, County Hospital Karlovac, Croatia.

Collegium Antropologicum
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mixing of arsenic-rich groundwater and surface water in drinking water distribution systems: Implications for contaminants, disinfection byproducts and organic components.

Chemosphere·2021
Same author

Secondary stroke in patients with polytrauma and traumatic brain injury treated in an Intensive Care Unit, Karlovac General Hospital, Croatia.

Injury·2015
Same author

BPC 157 therapy to detriment sphincters failure-esophagitis-pancreatitis in rat and acute pancreatitis patients low sphincters pressure.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2011
Same author

High hepatotoxic dose of paracetamol produces generalized convulsions and brain damage in rats. A counteraction with the stable gastric pentadecapeptide BPC 157 (PL 14736).

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2010
Same author

Over-dose insulin and stable gastric pentadecapeptide BPC 157. Attenuated gastric ulcers, seizures, brain lesions, hepatomegaly, fatty liver, breakdown of liver glycogen, profound hypoglycemia and calcification in rats.

Journal of physiology and pharmacology : an official journal of the Polish Physiological Society·2010
Same author

On the number of multilinear partitions and the computing capacity of multiple-valued multiple-threshold perceptrons.

IEEE transactions on neural networks·2008

Post-cholecystectomy, vitamin E levels significantly decreased in female patients regardless of anesthesia type. This study tracked vitamin E and liver enzyme changes after halothane or isoflurane anesthesia.

Area of Science:

  • Anesthesiology and Perioperative Medicine
  • Clinical Biochemistry
  • Nutritional Science

Background:

  • Cholecystectomy is a common surgical procedure.
  • Anesthetic agents can potentially influence biochemical markers.
  • Vitamin E's role in cellular protection warrants investigation in surgical contexts.

Purpose of the Study:

  • To evaluate the impact of halothane versus isoflurane anesthesia on vitamin E concentrations in female patients undergoing cholecystectomy.
  • To assess changes in liver enzyme activities (ALT, AST, GGT) post-surgery in relation to anesthetic choice.

Main Methods:

  • Randomized study involving 32 female patients (age 30-60, ASA I) undergoing cholecystectomy.
  • Vitamin E levels measured pre-operatively and at 1, 5, 24 hours, and 4 days post-surgery.

Related Experiment Videos

  • High-pressure liquid chromatography used for vitamin E determination; liver enzymes (ALT, AST, GGT) also analyzed.

    • Main Results:

    • A statistically significant decrease in vitamin E concentrations was observed at all measured time points post-surgery compared to pre-operative values (P < 0.05 to P < 0.01).
    • The lowest vitamin E levels occurred 24 hours post-operation, with slightly higher, though not statistically significant, levels in the isoflurane group.
    • No significant differences in liver enzyme activities (ALT, AST, GGT) were found between the anesthetic groups or over time.

    Conclusions:

    • Cholecystectomy under both halothane and isoflurane anesthesia leads to a significant reduction in circulating vitamin E levels.
    • The observed changes in vitamin E are time-dependent, with a nadir at 24 hours post-surgery.
    • Anesthetic choice (halothane vs. isoflurane) does not appear to significantly impact post-operative vitamin E levels or liver enzyme activity.