Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pericardial involvement in systemic sclerosis

R J Byers1, D A Marshall, A J Freemont

  • 1Department of Pathological Sciences, University of Manchester.

Annals of the Rheumatic Diseases
|June 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Standardizing health outcomes for people with rheumatoid arthritis receiving disease modifying drug therapy: A rapid review of patient-decision aids and preference studies to inform the development of OMERACT Health Outcome Descriptors.

Seminars in arthritis and rheumatism·2025
Same author

Managing juvenile idiopathic arthritis within the context of their life: What we learnt from children and youth living with juvenile idiopathic arthritis and their parents.

Musculoskeletal care·2023
Same author

Do people with knee osteoarthritis use guideline-consistent treatments after an orthopaedic surgeon recommends nonsurgical care? A cross-sectional survey with long-term follow-up.

Osteoarthritis and cartilage open·2022
Same author

Transitions from pediatric to adult rheumatology care for juvenile idiopathic arthritis: a patient led qualitative study.

BMC rheumatology·2022
Same author

Are education, exercise and diet interventions a cost-effective treatment to manage hip and knee osteoarthritis? A systematic review.

Osteoarthritis and cartilage·2020
Same author

Are medical comorbidities contributing to the use of opioid analgesics in patients with knee osteoarthritis?

Osteoarthritis and cartilage·2020

Systemic sclerosis frequently causes chronic pericarditis and myocardial fibrosis, suggesting it is a primary cardiac manifestation rather than secondary to kidney disease.

Area of Science:

  • Rheumatology
  • Cardiology
  • Pathology

Background:

  • Systemic sclerosis is a multisystem autoimmune disease characterized by fibrosis.
  • Cardiac involvement is a significant cause of morbidity and mortality in systemic sclerosis.
  • The specific pathology of pericardial involvement in systemic sclerosis requires further elucidation.

Purpose of the Study:

  • To investigate the frequency and histological features of pericardial disease in systemic sclerosis.
  • To differentiate systemic sclerosis-related pericarditis from other causes, such as uraemic pericarditis.
  • To explore the potential role of fibrosis and mast cells in the pathogenesis of cardiac involvement.

Main Methods:

  • Histological examination of pericardial autopsy sections from 44 systemic sclerosis patients and 19 controls.

Related Experiment Videos

  • Staining techniques included haematoxylin and eosin, acid toluidine blue, and elastic van Gieson.
  • Quantification of mast cells and fibrosis using mast cell counts and Chalkley scoring.

    • Main Results:

    • Chronic pericarditis was observed in 77.5% of systemic sclerosis cases, compared to 1 control.
    • Increased pericardial fibrosis was noted in systemic sclerosis patients; mast cell numbers were similar.
    • Myocardial fibrosis was present in 37.5% of systemic sclerosis cases, absent in controls.

    Conclusions:

    • Pericarditis and myocardial fibrosis are significantly more prevalent in systemic sclerosis.
    • These findings suggest pericarditis in systemic sclerosis is a primary cardiac manifestation.
    • The results underscore the importance of cardiac evaluation in systemic sclerosis management.