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Related Experiment Videos

Autonomic reactivity and hormonal secretion in lactate-induced panic attacks

F E Seier1, M Kellner, A Yassouridis

  • 1Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany.

The American Journal of Physiology
|June 1, 1997
PubMed
Summary

Lactate-induced panic attacks increase atrial natriuretic hormone (ANH) levels, a hormone that may inhibit sympathetic activity and cortisol release, potentially explaining panic attack symptoms. This study compared autonomic and neuroendocrine responses in panic disorder patients and controls.

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Area of Science:

  • Neuroendocrinology
  • Autonomic Nervous System Physiology
  • Psychiatry

Background:

  • Panic attacks involve complex autonomic and neuroendocrine changes.
  • Lactate infusion is a known method for inducing panic-like symptoms in susceptible individuals.
  • The role of hormones like atrial natriuretic hormone (ANH) in panic pathophysiology requires further elucidation.

Purpose of the Study:

  • To compare autonomic and neuroendocrine responses during lactate-induced panic attacks.
  • To investigate the relationship between heart rate variability, cortisol, and ANH levels in panic patients versus controls.

Main Methods:

  • Randomized, double-blind, placebo-controlled study.
  • Lactate or saline infusion administered to panic patients and healthy controls.

Related Experiment Videos

  • Measurements included spectral analysis of heart rate variability (HRV) and plasma levels of cortisol and ANH.

    • Main Results:

    • Lactate infusion accelerated heart rate and reduced overall HRV spectral power in both groups.
    • Panic patients showed increased high-frequency HRV power and significantly elevated ANH levels post-infusion.
    • Non-panickers exhibited a shift in HRV power distribution; cortisol levels remained unaffected in both groups.

    Conclusions:

    • Lactate-induced panic attacks are associated with increased ANH release.
    • ANH may play a role in attenuating sympathetic activity and cortisol secretion during panic attacks.
    • These findings may help explain the dissociation between psychological and physiological responses in panic disorder.