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Cerebral blood flow in single and multiple lacunar infarctions
Y Mochizuki1, M Oishi, T Takasu
1Department of Neurology, Nihon University School of Medicine, Tokyo, Japan. LEF00015@niftyserve.or.jp
Stroke
|July 1, 1997
Summary
Multiple lacunar infarctions are associated with higher rates of diabetes mellitus and reduced cerebral blood flow compared to single lacunar infarctions. These findings highlight key differences in underlying conditions and brain perfusion.
Area of Science:
- Neurology
- Cerebrovascular Diseases
- Medical Imaging
Background:
- Lacunar infarctions are small strokes often associated with hypertension and diabetes.
- Distinguishing between single and multiple lacunar infarctions may reveal differences in etiology and pathophysiology.
Purpose of the Study:
- To investigate the differences in underlying diseases and regional cerebral blood flow between single and multiple lacunar infarctions.
Main Methods:
- A comparative study involving 15 single lacunar infarction cases, 10 multiple lacunar infarction cases, and 16 control subjects.
- Regional cerebral blood flow (rCBF) was measured using the stable xenon CT method within 14 days of stroke onset.
Main Results:
- The prevalence of diabetes mellitus was significantly higher in the multiple lacunar infarction group.
- Mean cerebral blood flow in the cerebral cortex was significantly lower in patients with multiple lacunar infarctions.
- The cerebrovascular reactivity to acetazolamide was diminished in the cerebral cortex of patients with multiple lacunar infarctions.
Conclusions:
- Significant differences exist in underlying pathologies, specifically diabetes mellitus prevalence, between single and multiple lacunar infarctions.
- Reduced cerebral blood flow and impaired cerebrovascular reserve are characteristic of multiple lacunar infarctions compared to single lacunar infarctions.