Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered behaviour in hamsters conceived and born in hypergravity

H N Sondag1, H A de Jong, W J Oosterveld

  • 1Vestibular Department ENT, University of Amsterdam, The Netherlands.

Brain Research Bulletin
|January 1, 1997
PubMed
Summary

Hypergravity exposure during development impairs hamster vestibular function, causing lasting deficits in swimming and air-righting reflexes. These behavioral changes persist even after returning to normal gravity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The vestibulo-ocular reflex of hypergravity rats.

Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology·2003
Same author

[Veterinary midwife brought to justice].

Tijdschrift voor diergeneeskunde·2003
Same author

The horizontal vestibulo-ocular reflex of hypergravity rat at different gravity levels.

Neuroscience letters·2001
Same author

Vestibular-induced behaviour of rats born and raised in hypergravity.

Brain research bulletin·2000
Same author

The effectiveness of piracetam in vertigo.

Pharmacopsychiatry·1999
Same author

Behaviour of adult hamsters subjected to hypergravity.

Journal of vestibular research : equilibrium & orientation·1999

Area of Science:

  • Vestibular Neuroscience
  • Developmental Biology
  • Gravitational Biology

Background:

  • Vestibular system development is sensitive to gravitational forces.
  • Understanding hypergravity's impact is crucial for space exploration and human health.

Purpose of the Study:

  • To investigate the effects of hypergravity on vestibular function and behavior in developing hamsters.
  • To determine if developmental exposure to hypergravity causes persistent behavioral alterations.

Main Methods:

  • Hamsters were conceived and born in either 2.5 G (hypergravity) or 1 G (normal gravity).
  • Four experimental groups were established: high load (HL), high short (HS), control (CON), and rotation (ROT).
  • Locomotor activity, swimming ability, and air-righting reflexes were assessed at 4 weeks old and periodically thereafter.

Related Experiment Videos

Main Results:

  • Hamsters exposed to hypergravity (HL and HS groups) exhibited disturbed swimming ability, including circling and reduced speed.
  • HL hamsters showed decreased activity and fewer correct air-rightings under 2.5 G.
  • Behavioral deficits in swimming and air-righting persisted for over 3 months in normal gravity.

Conclusions:

  • Embryonal development in a hypergravity environment causes persistent behavioral disturbances in hamsters.
  • Hypergravity and rotation have distinct effects on behavioral development.
  • Vestibular system adaptations to hypergravity during development have long-lasting consequences.