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Related Experiment Videos

Brain MRI changes in chronic liver disease

S Skehan1, S Norris, J Hegarty

  • 1Department of Diagnostic Imaging, St. Vincent's Hospital, Elm Park, Dublin 4, Ireland.

European Radiology
|January 1, 1997
PubMed
Summary

Abnormal globus pallidus MRI signals occur in chronic liver disease, even before cirrhosis. These T1-weighted imaging changes can improve after liver transplantation.

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Area of Science:

  • Radiology
  • Hepatology
  • Neurology

Background:

  • Patients with cirrhosis often exhibit high signal intensity in the globus pallidus on T1-weighted MRI.
  • This finding is typically associated with chronic liver disease.

Purpose of the Study:

  • To investigate the relationship between MRI signal changes in the globus pallidus and clinical/pathological features of chronic liver disease.
  • To determine if these MRI abnormalities are present in patients before the development of cirrhosis.

Main Methods:

  • Non-contrast T1-weighted Magnetic Resonance Imaging (MRI) was used.
  • MR images were analyzed for signal intensity in the globus pallidus.
  • Patients with various stages of chronic liver disease were included.

Main Results:

  • Abnormally high globus pallidus signal on T1-weighted MRI was observed in 25 out of 28 patients with chronic liver disease.
  • These changes were present in patients with and without clinical portosystemic shunting.
  • Cholestatic liver disease was associated with more pronounced MRI signal changes compared to non-cholestatic disease.
  • No significant correlation was found between liver disease severity and the degree of MRI abnormality.
  • Significant improvement in MRI findings was noted post-liver transplantation.

Conclusions:

  • High globus pallidus signal on T1-weighted MRI is a common finding in chronic liver disease, not exclusive to cirrhosis.
  • These MRI changes are not the cause of hepatic encephalopathy.
  • Successful liver transplantation can lead to the resolution of these globus pallidus MRI abnormalities.

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