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Assessment of proliferative activity, DNA values and some clinicopathologic parameters in mesenchymal tumors.
A Niezabitowski1, J Ryś, A Roessner
1Department of Tumor Pathology, Oncology Center, Cracow, Poland.
General & Diagnostic Pathology
|June 1, 1997
Abstract:
Clinicopathologic parameters of 70 consecutive mesenchymal tumors from 63 patients were evaluated. In all these cases, the DNA content was analyzed by flow cytometry, and the expression of proliferative antigen MIB1 and p53 protein was assessed by immunohistochemistry. Our study verified the prognostic usefulness of proliferative indicators, above all MIB1-index, which strongly correlated with tumor grade and independently influenced overall survival.