Related Experiment Video
Updated: Jul 16, 2026
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Methacholine challenge testing: safety of low starting FEV1. Asthma Clinical Research Network (ACRN)
R J Martin1, J S Wanger, C G Irvin
1National Jewish Center for Immunology and Respiratory Medicine, Denver, CO 80206, USA.
Study Objective:
The lower limit for the baseline value to initiate methacholine bronchial hyperresponsiveness testing has not been well established. Recommendations have varied from > 1 L to above 80% of predicted. The objective was to determine if an FEV1 < 60% predicted was acceptable.
Design:
Retrospective analysis of challenges in 88 patients with a baseline FEV1 of < 60% predicted (mean=45.8%; range, 22 to 59%.
Setting:
Academic institutions.
Results:
There were only four individuals whose FEV1 did not return to > 90% of baseline following one poststudy beta2-agonist treatment. All four responded to a second treatment. There were no adverse sequelae following challenge in any individual. Neither age (up to 79 years) nor gender influenced outcome.
Conclusions:
In chronic moderate to severe asthma, it appears that bronchial hyperresponsiveness testing can be safely performed even in those patients with a low baseline FEV1.
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