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Gestational diabetes and preterm labour: is glycaemic control a contributing factor?
I Bar-Hava1, Y Barnhard, S A Scarpelli
1Department of Obstetrics and Gynecology, Albert Einstein College of Medicine, Bronx, New York, USA.
Summary
Intensively-treated gestational diabetes mellitus (GDM) patients show no increased risk of preterm delivery. Glycaemic control did not differ between GDM patients who delivered preterm versus at term.
Area of Science:
- Obstetrics and Gynecology
- Endocrinology
- Perinatal Medicine
Background:
- Gestational diabetes mellitus (GDM) is a common pregnancy complication.
- Preterm delivery poses significant risks to both mother and neonate.
- The relationship between glycemic control in GDM and preterm birth requires further elucidation.
Purpose of the Study:
- To evaluate the incidence of preterm delivery in women with GDM.
- To determine the association between glycemic control and preterm delivery in GDM patients.
Main Methods:
- Retrospective cohort study comparing GDM patients to a non-GDM control group.
- Incidence of spontaneous preterm singleton deliveries assessed in 550 GDM patients and 14,552 controls.
- Glycemic profiles (mean glucose, hypo/hyperglycemic episodes) compared between 34 GDM preterm and 68 GDM term deliveries.
Main Results:
- The incidence of preterm delivery was similar between GDM patients (6.2%) and the control population (6.5%).
- Glycemic profiles were comparable between GDM patients who delivered preterm and those who delivered at term, both overall and in the week prior to delivery.
Conclusions:
- Intensive treatment of GDM does not appear to increase the risk of preterm delivery.
- Glycemic control, as assessed by routine profiles, does not differentiate GDM patients who deliver preterm from those who deliver at term.