Related Experiment Videos
Immunohistochemical analysis of glutathione S-transferase mu expression in ovarian tumors
T Matsumoto1, R Hayase, J Kodama
1Department of Obstetrics and Gynecology, Okayama University Medical School, Japan.
Objective:
To explore the association between Glutathione S-transferase (GST) -mu expression and clinicopathologic features in ovarian tumors.
Study Design:
Immunohistochemical study was made to investigate GST-mu expression in diverse ovarian tumors.
Results:
All 75 ovarian tumors expressed GST-mu. There was no significant association between GST-mu immunopositivity and clinicopathological features. In serous cystadenocarcinoma, however, patients with weak GST-mu expression survived longer than those with moderate or strong GST-mu expression. Three of the 8 tumors that had expressed weak GST-mu initially increased GST-mu expression after chemotherapy.
Conclusion:
GST-mu expression is common in ovarian tumors and malignant tumors expressed more GST-mu than benign tumors. GST-mu might play a major role in the development of drug resistance in certain ovarian tumors and could be a useful marker of natural resistance and their future outcome.