Non-random deletions in human foamy virus long terminal repeat during viral infection

J De Celis-Kosmas¹, A Coronel, I Grigorian

¹UPR 9051, CNRS, Hôpital Saint-Louis, Paris, France.

|January 1, 1997

Abstract:

We have characterized a new form of human foamy virus (HFV) non-random deleted long terminal repeat (LTR) sizing 1078-bp, deleted in its U3 region, sensitive to the viral transactivator and functional in an infectious proviral clone. Besides two known HFV LTRs of 1260-bp and 1123-bp, this LTR represents the smallest, designed S. Analysis of the LTR sequence shows the presence of short direct repeats surrounding the deletions, suggesting a mechanism generating deletion by misalignment of the growing strand during replication. Our data suggest that the deleted LTRs, preferentially associated with chronic viral infection, could be related with viral persistence.

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Abstract:

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