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Bovine rotavirus strain 678 possesses VP4 of serotype P7[5] specificity
T Nakagomi1, O Nakagomi, H J Streckert
1Department of Microbiology, Akita University School of Medicine, Japan.
Archives of Virology
|January 1, 1997
Abstract:
Bovine rotavirus strain 678 is the first G8 strain of bovine origin but the literature is confusing as to its P type. In this study, two-way cross neutralization between 678 and 0510, a prototype G6P7[5] virus, was shown by plaque-reduction neutralization assays, establishing the P type of 678 as being P7[5]. The P7[5] specificity of 678 VP4 was reinforced by the finding that the VP8* portion of 678 VP4 had the highest amino acid identity with those of P7[5] bovine rotaviruses. Apparent contradiction with previous serological studies relates to intricacy of antigenicity and immunogenicity of UK VP4 in reassortants.