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Paget's disease of bone

W D Fraser1

  • 1Department of Clinical Chemistry, Royal Liverpool University Hospital, United Kingdom.

Current Opinion in Rheumatology
|July 1, 1997
PubMed
Summary

Paget

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Area of Science:

  • Bone biology and genetics
  • Viral etiology of bone diseases
  • Clinical management of metabolic bone disorders

Background:

  • Paget's disease of bone shows decreasing incidence globally, with highest rates historically in the UK.
  • Genetic factors, including HLA locus and 18q, are implicated in susceptibility.
  • Potential viral triggers, such as measles virus and canine distemper virus, are under investigation.

Purpose of the Study:

  • To review the epidemiology, etiology, and management of Paget's disease of bone.
  • To explore genetic and infectious factors contributing to the disease.
  • To assess current therapeutic strategies and their efficacy.

Main Methods:

  • Review of epidemiological data on Paget's disease incidence and geographic distribution.
  • Analysis of genetic studies identifying susceptibility loci.
  • Investigation of molecular evidence linking paramyxoviruses (measles, canine distemper) to disease etiology.
  • Evaluation of clinical outcomes and response to bisphosphonate therapies.

Main Results:

  • Decreasing global incidence and severity of Paget's disease noted.
  • Strong genetic links identified on chromosomes 6 and 18q.
  • Evidence suggests a role for paramyxoviruses, with canine distemper virus as a potential agent.
  • Familial cases present with greater severity; quality of life can be impacted.
  • Bisphosphonates are the most effective treatment, with newer agents showing promise.

Conclusions:

  • Paget's disease is influenced by genetic predisposition and potentially viral infections.
  • Effective management relies on bisphosphonate therapy, with ongoing research into etiology.
  • Understanding risk factors and disease mechanisms is crucial for improved patient outcomes.

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