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Sigmoid diverticular perforation complicating lung transplantation
1Department of Medicine, University of Florida College of Medicine, Gainesville 32610-0225, USA.
Summary
Lung transplant recipients experienced sigmoid colonic diverticular perforation early post-transplant. This study highlights an 8.6% incidence, higher than other transplant populations, possibly due to immunosuppression and other factors.
Area of Science:
- Gastroenterology
- Transplant Surgery
- Immunology
Background:
- Sigmoid colonic diverticular perforation is a rare but serious complication.
- The incidence and timing of this complication in lung transplant recipients are not well-established.
Observation:
- Three lung transplant recipients developed sigmoid colonic diverticular perforation within four weeks of transplantation.
- This represents an incidence of 8.6% in the study population.
Findings:
- The early occurrence and higher incidence in lung transplant recipients are unusual compared to other transplant populations.
- Potential contributing factors include intense post-transplantation immunosuppression, perioperative hypoperfusion, and increased intraluminal pressure from medications.
Implications:
- This suggests a need for increased vigilance for gastrointestinal complications in early post-lung transplant period.
- Further research is warranted to elucidate the exact causes and develop preventive strategies.