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The French experience with infusional 5-fluorouracil in advanced colorectal cancer
A de Gramont1, C Louvet, M Krulik
1Service de Médecine Interne-Oncologie, Hôpital Saint-Antoine, Paris, France.
Abstract:
The French contribution to the development of 5-fluorouracil (5-FU) infusion in advanced colorectal cancer includes five randomized trials and specific researches on the 48-hour bimonthly regimen, chronotherapy, and individual dose adaptation. The bimonthly 48-hour LV5-FU bolus and infusion is the standard treatment outside the research protocols and the control arm of the ongoing trials.
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