[Efficacy of cordipin chronotherapy with reference to anginal patients' chronosensitivity]

A randomized trial has been conducted of cordipin conventional treatment versus chronotherapy in 40 patients with coronary heart disease, angina pectoris (class II and III), progressive angina. The patients entered 2 groups. Group 1 have received conventional treatment with cordipin in a dose 10 mg 3 times a day, group 2 patients received cordipin once a day in a dose 10 mg depending on their chronosensitivity to this drug, i.e. in the period of the highest hemodynamic activity of cordipin. Chronosensitivity to cordipin was determined in acute clinicopharmaceutical tests once a day for 4 days. As shown by chest tetrapolar rheography, echocardiography, exercise tolerance chronotherapy is effective because the antianginal effect was achieved 2 times more rapidly with 3 times reduced daily and course doses. Moreover, more potent hemodynamic support of the antianginal effect is provided.