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[Penicillin resistance in strains of Streptococcus pneumoniae]
B Tomanović1, V Mirović, Z Nonković
1Vojnomedicinska akademija, Zavod za preventivnu medicinu, Institut za mikrobiologiju, Beograd.
Abstract:
The values of minimal inhibitory concentration (MIC) of penicillin were determined using the agar-dilution method for 114 strains of Streptococcus pneumoniae isolated during 1994 in the patients treated in hospital and outpatient clinics. Diminished susceptibility to penicillin was determined in 50 (43.8%) strains. High level of penicillin resistance was observed in 12 (10.5%) strains. Streptococcus pneumoniae cannot any more be regarded as the agent with presumed susceptibility to penicillin, but every isolated strain must be tested.
Insights
Penicillin resistance in Streptococcus pneumoniae is increasing, with over 43% of strains showing reduced susceptibility and 10% highly resistant. Routine testing of every isolate is now essential for effective treatment.
Area of Science:
- Microbiology
- Infectious Diseases
- Antimicrobial Resistance
Context:
- 114 strains of Streptococcus pneumoniae were analyzed.
- Isolates were collected from hospital and outpatient clinics in 1994.
- The study focused on penicillin susceptibility patterns.
Purpose:
- To determine the prevalence of penicillin resistance in Streptococcus pneumoniae.
- To assess the need for routine susceptibility testing.
Summary:
- Minimal inhibitory concentration (MIC) of penicillin was determined using agar-dilution.
- Reduced susceptibility was found in 50 (43.8%) strains.
- High-level penicillin resistance was observed in 12 (10.5%) strains.
Impact:
- Streptococcus pneumoniae can no longer be assumed to be penicillin-susceptible.
- Individual strain testing is crucial for guiding antibiotic therapy.
- Highlights the growing challenge of antimicrobial resistance.