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Activated factor VII levels in patients with angiographically confirmed coronary artery disease

J E Eichner1, W E Moore, E Schechter

  • 1Department of Biostatistics and Epidemiology, College of Public Health, University of Oklahoma, Oklahoma Medical Research Foundation, and the Oklahoma City Veterans Hospital, 73190, USA.

The American Journal of Cardiology
|July 15, 1997
PubMed

Insights

Factor VIIa levels did not correlate with coronary artery narrowing in patients undergoing angiography. This finding suggests factor VIIa is not a reliable biomarker for coronary artery disease severity.

Area of Science:

  • Cardiovascular Medicine
  • Hematology
  • Biochemistry

Background:

  • Factor VIIa is a key enzyme in the blood coagulation cascade.
  • Elevated levels of coagulation factors have been implicated in thrombotic events, including coronary artery disease.

Purpose of the Study:

  • To investigate the relationship between factor VIIa levels and the presence and severity of coronary arterial narrowing.
  • To determine if factor VIIa serves as a biomarker for coronary artery disease.

Main Methods:

  • A cohort of 702 patients undergoing coronary angiography provided informed consent.
  • Blood samples were analyzed to measure factor VIIa levels.
  • Coronary arterial narrowing was assessed by the degree and extent of stenosis.

Main Results:

  • Patients with clinically defined coronary artery disease (>= 50% stenosis) showed similar factor VIIa levels compared to those with less stenosis or normal arteries.
  • No significant correlation was found between factor VIIa levels and the degree or extent of coronary arterial narrowing in both men and women.

Conclusions:

  • Factor VIIa levels do not appear to be associated with the presence or severity of coronary artery disease.
  • Factor VIIa may not be a useful biomarker for predicting or assessing coronary arterial narrowing.

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