Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple pathways of capillary permeability

E M Renkin

    Circulation Research
    |December 1, 1977
    PubMed
    Summary
    This summary is machine-generated.

    Capillary transport involves multiple pathways, but the specific roles of endothelial cell membranes and intercellular junctions remain unclear. Further research is needed to identify the morphological basis of these transport routes.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Transcapillary exchange in relation to capillary circulation.

    The Journal of general physiology·2009
    Same author

    Eugene M. Landis and the physiology of the microcirculation.

    American journal of physiology. Heart and circulatory physiology·2004
    Same author

    Measurement of microvascular transport parameters of macromolecules in tissues and organs of intact animals.

    Microcirculation (New York, N.Y. : 1994)·1998
    Same author

    Interstitial exclusion of macromolecules studied by graded centrifugation of rat tail tendon.

    The American journal of physiology·1998
    Same author

    Atrial natriuretic peptide levels and plasma volume contraction in acute alveolar hypoxia.

    Journal of applied physiology (Bethesda, Md. : 1985)·1997
    Same author

    Acute alveolar hypoxia increases blood-to-tissue albumin transport: role of atrial natriuretic peptide.

    Journal of applied physiology (Bethesda, Md. : 1985)·1997
    Same journal

    Mitochondrial STING Governs Glycolytic Reprogramming in Diabetic Cardiomyopathy.

    Circulation research·2026
    Same journal

    Hypoxia-Induced Epas1-Myl9/12 Axis Shapes the Pathology of Pulmonary Hypertension.

    Circulation research·2026
    Same journal

    Proteogenomics of Hypertrophic Cardiomyopathy Reveals Subtype-Specific Therapy.

    Circulation research·2026
    Same journal

    Impaired Endothelial Cell Cholesterol Metabolism Promotes Vascular Inflammation in Sleep Apnea.

    Circulation research·2026
    Same journal

    Engineered Heart Tissues Facilitate Noncoding Variant Studies in Cardiomyopathy.

    Circulation research·2026
    Same journal

    NUAK1 Inhibition Alleviates Ischemia-Reperfusion Injury via SYNE1-YAP1.

    Circulation research·2026
    See all related articles

    Area of Science:

    • Physiology
    • Cell Biology
    • Biophysics

    Background:

    • Capillary endothelium facilitates transport via multiple routes.
    • Specific morphological pathways for endothelial transport are not fully identified.
    • The roles of endothelial cell membranes and intercellular junctions in transport are not well-defined.

    Purpose of the Study:

    • To evaluate the contribution of endothelial cell membranes to the transport of water and small, lipid-insoluble molecules.
    • To clarify the association between intercellular junctions and the 'small pore' pathway.
    • To determine the contribution of various structures (junctions, vesicles, fenestrae) to macromolecular transport.

    Main Methods:

    • Morphological studies of capillary endothelium.
    • Physiological assessments of transport processes.

    Related Experiment Videos

  • Analysis of intercellular junctions, vesicles (pinocytosis, transcytosis), and fenestrae.

    • Main Results:

    • Multiple transport routes across capillary endothelium are suggested by morphological and physiological data.
    • The precise morphological counterparts of specific transport processes are not fully established.
    • The contribution of endothelial cell membranes to water and small molecule transport requires further investigation.
    • The link between intercellular junctions and the 'small pore' pathway remains uncertain.
    • The quantitative contributions of junctions, vesicles, and fenestrae to macromolecular transport are unknown.

    Conclusions:

    • Significant gaps exist in understanding the morphological basis of endothelial transport.
    • Further research is essential to elucidate the roles of endothelial cell membranes, intercellular junctions, and vesicular transport in capillary permeability.
    • Accurate characterization of these pathways is crucial for understanding physiological and pathological conditions involving capillaries.