A computer program for constructing multivariate reference models
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Updated: Oct 23, 2026

Basics of Multivariate Analysis in Neuroimaging Data
Published on: July 24, 2010
M Hekking1, J Lindemans, E S Gelsema
1Department of Medical Informatics, Erasmus University, Rotterdam, Netherlands. hekking@mi.fgg.eur.nl
Abstract:
From a statistical point of view the simultaneous interpretation of multiple variables should be performed with a multivariate reference model rather than with multiple univariate reference intervals. A computer program for constructing and testing multivariate reference models is described. The use of the computer program is illustrated with a data set of total serum calcium concentrations and serum albumin concentrations from 222 2nd year medical students. Using a single univariate reference interval for total serum calcium, 17 students were classified as having an abnormal calcemic status while using a bivariate reference model for total serum calcium and serum albumin, 13 of these 17 students had in fact normal total serum calcium concentrations, taking into account their serum albumin concentrations.
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