Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Folded structures in protonated reduced dipeptides

V Grand1, A Aubry, V Dupont

  • 1Laboratory of Macromolecular Physical Chemistry, ENSIC-INPL, Nancy, France.

Journal of Peptide Science : an Official Publication of the European Peptide Society
|November 1, 1996
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinical relevance and prognostic impact of the classification between multibacillary and paucibacillary forms of cutaneous tuberculosis: A 24-year retrospective multicenter study.

Annales de dermatologie et de venereologie·2024
Same author

Lessons learned from treating drug-resistant TB and how to apply these to drug-susceptible TB.

The international journal of tuberculosis and lung disease : the official journal of the International Union against Tuberculosis and Lung Disease·2024
Same author

Comparison of greenhouse gas emissions from sheep measured using both respiration and portable accumulation chambers.

Animal : an international journal of animal bioscience·2024
Same author

Klebsiella aerogenes-related facial folliculitis in men having sex with men: A hypothetical new STI?

Journal of the European Academy of Dermatology and Venereology : JEADV·2024
Same author

Machine learning to improve the interpretation of intercalating dye-based quantitative PCR results.

Scientific reports·2022
Same author

Effect of rumen fluke on feed digestibility and methane emissions in sheep.

Parasitology research·2022
Same journal

Integrative Identification of Anti-Photoaging Peptides From Stress-Tolerant Microorganisms via Machine Learning and KEAP1-NRF2 Docking.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same journal

Cementum Attachment Protein-Derived Peptides Modulate Brushite and Calcium Oxalate Crystallization In Vitro.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same journal

Nanostructure and Collagen-Stimulating Activity of Cationic Pentapeptide Lipopeptides.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same journal

Reductive Methylation: An Alternative to Lysine → Arginine Mutagenesis.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same journal

Radiolabeled Angiopep-2 Peptide Vector as a Preclinical Platform for Blood-Brain Barrier Targeting: Synthesis, Radiolabeling, and Preliminary In Vivo Biodistribution in Mice.

Journal of peptide science : an official publication of the European Peptide Society·2026
Same journal

Formulation of Peptide-Based Nanoparticles Using a Microfluidic Device.

Journal of peptide science : an official publication of the European Peptide Society·2026
See all related articles

Reduced dipeptides adopt folded conformations, mimicking peptide turns. Their protonated amide bonds form strong hydrogen bonds, influencing molecular structure in solution and solid states.

Area of Science:

  • Chemical Biology
  • Structural Biology
  • Peptide Chemistry

Background:

  • Dipeptides are fundamental peptide units.
  • Understanding peptide conformation is crucial for drug design.
  • Reduced amide bonds offer unique structural properties.

Purpose of the Study:

  • To investigate the conformational behavior of reduced dipeptides.
  • To explore the hydrogen bonding capabilities of protonated reduced amide bonds.
  • To compare the resulting structures to known peptide turns.

Main Methods:

  • Synthesis of reduced dipeptides with the general formula RCO-Xaa-rXbb-N+HR'R".
  • Conformational analysis in solution and solid states.
  • Spectroscopic and crystallographic techniques (implied).

Related Experiment Videos

Main Results:

  • Reduced dipeptides were synthesized and characterized.
  • These molecules adopt stable folded conformations.
  • The protonated reduced amide bond acts as a potent hydrogen bond donor.
  • Hydrogen bonding interactions are topologically similar to i+2 or i+3-->i interactions in peptides.
  • The observed conformations resemble gamma- or beta-turns.

Conclusions:

  • Reduced dipeptides can form stable, turn-like structures.
  • The protonated reduced amide bond is key to this conformational preference.
  • These findings have implications for peptide mimetics and structural biology.