Related Experiment Videos
Rapid increase in inspired desflurane concentration does not elicit a hyperdynamic circulatory response in the pig
W Karzai1, J Haberstroh, W Müller
1Department of Anaesthesiology, University Hospital, Freiburg, Germany.
Laboratory Animals
|July 1, 1997
Summary
A rapid increase in desflurane concentration did not significantly alter heart rate or plasma catecholamines in pigs. However, mean arterial pressure immediately decreased, contrasting with human responses.
Area of Science:
- Veterinary Anesthesiology
- Cardiovascular Physiology
- Pharmacology
Background:
- Desflurane is a volatile anesthetic agent.
- Rapid increases in desflurane concentration can affect hemodynamics in humans.
- The physiological response in pigs to rapid desflurane increases is not well-characterized.
Purpose of the Study:
- To investigate the effects of a rapid increase in inspired desflurane concentration on systemic hemodynamics and plasma catecholamines in pigs.
- To compare the hemodynamic response in pigs to that observed in humans.
Main Methods:
- Seven pigs (22-30 kg) were anesthetized and instrumented for hemodynamic monitoring and blood sampling.
- Inspired desflurane concentration was abruptly increased from 3% to 15%.
- Mean arterial pressure, heart rate, and plasma epinephrine and norepinephrine levels were measured before and after the increase.
Main Results:
- Heart rate showed an insignificant 11% increase at 1, 2, and 4 minutes post-increase.
- Mean arterial pressure demonstrated an immediate decrease.
- Plasma concentrations of epinephrine and norepinephrine remained unchanged throughout the study.
Conclusions:
- In pigs, a rapid increase in inspired desflurane concentration does not induce a hyperdynamic circulatory response.
- The hemodynamic response in pigs differs from that observed in humans, with a decrease in blood pressure rather than an increase.