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Related Experiment Videos

Annexin gene structures and molecular evolutionary genetics

R O Morgan1, M P Fernández

  • 1Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Oviedo, Spain. mpff@dwarfl.quimica.uniovi.es

Cellular and Molecular Life Sciences : CMLS
|June 1, 1997
PubMed
Summary

Annexins, a multigene family, show extensive evolution through gene duplication and divergence. Their conserved structure over 1200 million years suggests a fundamental role, aiding studies in molecular evolution and hereditary phenotypes.

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Area of Science:

  • Molecular Biology
  • Evolutionary Biology
  • Genomics

Background:

  • Annexins are a multigene family found across eukaryotic genomes.
  • Their gene structure and sequence data offer insights into molecular evolution.
  • Studying annexins provides a model for understanding multigene family dynamics.

Purpose of the Study:

  • To reconstruct the phylogenetic history of annexin genes.
  • To investigate the evolutionary processes of gene duplication and divergence within the annexin family.
  • To determine the evolutionary rates and duplication timings for vertebrate annexins.

Main Methods:

  • Phylogenetic reconstruction using abundant coding sequences.
  • Computational and cladistic sequence analyses.

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  • Analysis of gene structure and homologous recombination patterns.

    • Main Results:

    • Annexin family expanded via gene duplication to over 27 subfamilies.
    • Strict preservation of core annexin structure for over 1200 million years.
    • Identification of unique 5' coding and regulatory regions facilitating adaptation.
    • Determination of gene duplication dates and mutation rates for vertebrate annexins.

    Conclusions:

    • Annexins exemplify molecular evolution in multigene families.
    • Conserved structure implies a basic, fundamental functional role.
    • Evolutionary studies of annexins can elucidate structure-function relationships, physiological roles, and link to hereditary phenotypes.