Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Urinary catecholamine excretion and behavioral differences in ADHD and normal boys

G L Hanna1, E M Ornitz, M Hariharan

  • 1Department of Psychiatry, University of Michigan, Ann Arbor 48109-0390, USA.

Journal of Child and Adolescent Psychopharmacology
|April 1, 1996
PubMed
Summary

Boys with attention-deficit/hyperactivity disorder (ADHD) showed lower urinary levels of DOPEG, a norepinephrine metabolite. These findings suggest altered catecholamine metabolism in ADHD, impacting behavioral symptoms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comprehensive study on structural, electronic, optical, elastic, and transport properties of natural mercury sulphohalides via DFT computation.

Scientific reports·2024
Same author

CT-based severity assessment for COVID-19 using weakly supervised non-local CNN.

Applied soft computing·2022
Same author

AI for COVID-19 Detection from Radiographs: Incisive Analysis of State of the Art Techniques, Key Challenges and Future Directions.

Ingenierie et recherche biomedicale : IRBM = Biomedical engineering and research·2021
Same author

Ischemic Lesion Segmentation using Ensemble of Multi-Scale Region Aligned CNN.

Computer methods and programs in biomedicine·2020
Same author

Congenital nasal pyriform aperture stenosis: a rare cause of neonatal nasal airway obstruction.

BJR case reports·2018
Same author

Improved binary dragonfly optimization algorithm and wavelet packet based non-linear features for infant cry classification.

Computer methods and programs in biomedicine·2018

Area of Science:

  • Neuroscience
  • Biochemistry
  • Pediatrics

Background:

  • Attention-deficit/hyperactivity disorder (ADHD) is a complex neurodevelopmental disorder.
  • Catecholamine metabolism, particularly norepinephrine (NE) and epinephrine (EPI), is implicated in ADHD.
  • Urinary dihydroxyphenylglycol (DOPEG), an NE metabolite, has not been previously studied in ADHD.

Purpose of the Study:

  • To investigate urinary catecholamine metabolite excretion in boys with ADHD compared to controls.
  • To determine the relationship between specific catecholamine metabolites and ADHD behavioral symptoms.

Main Methods:

  • Assessed urinary catecholamine excretion (including DOPEG, NE, EPI) in 15 boys with ADHD and 16 controls.
  • Utilized high-pressure liquid chromatography with electrochemical detection for precise metabolite quantification.

Related Experiment Videos

  • Employed stepwise multiple regression analysis to link metabolite levels with behavioral symptoms.

    • Main Results:

    • ADHD subjects exhibited significantly lower urinary DOPEG concentrations than normal controls.
    • A trend towards lower urinary EPI levels was observed in boys with ADHD.
    • Both DOPEG and EPI levels significantly contributed to the variance in behavioral symptoms.

    Conclusions:

    • Findings suggest abnormal norepinephrine and epinephrine metabolism in ADHD.
    • Neurochemical differences may stem from variations in neuronal or non-neuronal activity.
    • Results highlight the need for caution in attributing metabolite changes solely to ADHD, considering potential overlap with normal childhood behaviors.