Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Current concepts in intestinal peptide absorption

G Fricker1, J Drewe

  • 1Institut für Pharmazeutische Technologie und Biopharmazie, Ruprecht-Karls-Universität, Heidelberg, Germany. jw3@ix.urz.uni.heidelberg.de

Journal of Peptide Science : an Official Publication of the European Peptide Society
|July 1, 1996
PubMed
Summary

Oral peptide delivery faces challenges with low bioavailability and variable plasma levels. This review explores absorption barriers, transport mechanisms, and pharmaceutical strategies for peptide and protein delivery.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Uncovering the molecular signature of feline diffuse iris melanoma through transcriptomic analysis of disease severity.

Scientific reports·2025
Same author

Immunoliposomes - a new therapeutic option to treat SynGAP1-associated epilepsy.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2025
Same author

Coating of PLA-nanoparticles with cyclic, arginine-rich cell penetrating peptides enables oral delivery of liraglutide.

Nanomedicine : nanotechnology, biology, and medicine·2019
Same author

Active animal health surveillance in European Union Member States: gaps and opportunities.

Epidemiology and infection·2016
Same author

A liposomal formulation for the oral application of the investigational hepatitis B drug Myrcludex B.

European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V·2016
Same author

Next Generation of SiFAlin-Based TATE Derivatives for PET Imaging of SSTR-Positive Tumors: Influence of Molecular Design on In Vitro SSTR Binding and In Vivo Pharmacokinetics.

Bioconjugate chemistry·2015

Area of Science:

  • Pharmacology
  • Biotechnology
  • Drug Delivery Systems

Background:

  • Oral peptide administration is highly desirable but limited by poor bioavailability and plasma level variability.
  • Peptides and proteins are prone to degradation in the gastrointestinal tract, hindering effective absorption.
  • Understanding these limitations is crucial for developing advanced oral delivery systems.

Purpose of the Study:

  • To review the major barriers affecting oral peptide absorption.
  • To elucidate the fundamental mechanisms of intestinal peptide transport.
  • To summarize current experimental models and pharmaceutical approaches for peptide and protein absorption.

Main Methods:

  • Comprehensive literature review of scientific publications.
  • Analysis of studies on peptide absorption barriers and transport mechanisms.

Related Experiment Videos

  • Evaluation of experimental models and pharmaceutical strategies.

    • Main Results:

    • Identified key physiological and biochemical barriers to oral peptide absorption.
    • Described various intestinal peptide transport pathways.
    • Cataloged diverse experimental models and pharmaceutical innovations.

    Conclusions:

    • Overcoming low bioavailability and high variability remains a significant challenge in oral peptide delivery.
    • Further research into transport mechanisms and novel pharmaceutical approaches is essential.
    • Advanced strategies are needed to improve oral absorption of peptides and proteins.