Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunologic regulation in pregnancy

D P Stites, C S Pavia, L E Clemens

    Arthritis and Rheumatism
    |November 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    A behavioral comparison of the common laboratory rat strains Lister Hooded, Lewis, Fischer 344 and Wistar in an automated homecage system.

    Genes, brain, and behavior·2013
    Same author

    Serologic detection of a rare case of Q fever in New York City having hepatic and unusual renal complications.

    Infection·2010
    Same author

    Keep cool: memory is retained during hibernation in Alpine marmots.

    Physiology & behavior·2009
    Same author

    History of aromatase: saga of an important biological mediator and therapeutic target.

    Endocrine reviews·2009
    Same author

    The role of the rheumatologist in managing arthritis.

    The Medical journal of Australia·2002
    Same author

    Placental characteristics and reduced risk of maternal breast cancer.

    Journal of the National Cancer Institute·2001
    Same journal

    Proceedings of the Annual Meeting of the American Rheumatism Association.

    Arthritis and rheumatism·2020
    Same journal

    The regional distribution of rheumatologists: what can we do, what should we do?

    Arthritis and rheumatism·2013
    Same journal

    Regional distribution of adult rheumatologists.

    Arthritis and rheumatism·2013
    Same journal

    Clinically significant renal involvement in primary Sjögren's syndrome: clinical presentation and outcome.

    Arthritis and rheumatism·2013
    Same journal

    Headache in systemic lupus erythematosus: results from a prospective, international inception cohort study.

    Arthritis and rheumatism·2013
    Same journal

    Association of low baseline levels of erythrocyte folate with treatment nonresponse at three months in rheumatoid arthritis patients receiving methotrexate.

    Arthritis and rheumatism·2013
    See all related articles

    Pregnancy involves complex immune adaptations, including uterine immunologic privilege and trophoblast antigen expression, to prevent fetal rejection. Hormones like human chorionic gonadotropin (HCG) may play a crucial role in immune tolerance.

    Area of Science:

    • Reproductive Immunology
    • Maternal-Fetal Medicine
    • Transplantation Immunology

    Background:

    • Pregnancy involves a unique maternal-fetal relationship where the mother's immune system must tolerate the semi-allogeneic fetus.
    • Several theories attempt to explain how the maternal immune system avoids rejecting the fetus, a semi-allogeneic graft.

    Purpose of the Study:

    • To review and discuss existing theories explaining the maternal immune system's tolerance of the fetus during pregnancy.
    • To explore the evidence supporting and refuting these theories.
    • To highlight the potential role of local hormonal factors in immune privilege.

    Main Methods:

    • Literature review and synthesis of existing research on reproductive immunology.
    • Discussion of evidence for and against established theories of immune tolerance in pregnancy.

    Related Experiment Videos

  • Analysis of the proposed mechanisms of immune suppression and modulation.

    • Main Results:

    • Theories include uterine immunologic privilege, lack of trophoblast antigen expression, maternal immune suppression, and maternal-fetal circulation separation.
    • Evidence supporting and contradicting each theory is presented.
    • Local hormone concentrations (e.g., human chorionic gonadotropin, sex steroids, alpha-fetoprotein) and other factors (progesterone, antibodies, immune complexes) are implicated in preventing maternal immune attack.

    Conclusions:

    • The failure of fetal rejection is likely multifactorial, involving a combination of mechanisms.
    • Local hormonal factors and immune modulators are crucial for maintaining placental and fetal protection.
    • Understanding these regulatory mechanisms in pregnancy may offer insights applicable to broader immunological challenges.