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Venous tone in essential hypertension
Insights
Peripheral venous tone decreases in advanced essential hypertension. Reserpine treatment normalized venous tone in stage IIA hypertensive patients, indicating a potential therapeutic target for managing blood pressure and venous function.
Area of Science:
- Cardiovascular Physiology
- Hypertension Research
- Clinical Pharmacology
Background:
- Essential hypertension is characterized by elevated arterial pressure.
- Peripheral venous tone plays a crucial role in circulatory regulation.
- Understanding venous tone alterations in hypertension is vital for comprehensive patient management.
Purpose of the Study:
- To investigate peripheral venous tone in patients with essential hypertension.
- To correlate venous tone with arterial pressure and disease stage.
- To evaluate the effect of reserpine on venous tone in hypertensive patients.
Main Methods:
- Digital electroplethysmography was used to measure peripheral venous tone.
- 124 patients with essential hypertension and 20 healthy controls were studied.
- Venous tone was assessed in different stages of hypertension and during orthostasis.
Main Results:
- A significant decrease in venous tone was observed with increasing arterial tone in stage II hypertension.
- Venous tone increased less than arterial tone during orthostasis.
- Reserpine treatment in stage IIA hypertension led to decreased arterial pressure and normalized venous tone.
Conclusions:
- Peripheral venous tone is significantly altered in essential hypertension, particularly in advanced stages.
- Venous capacity correlates with systolic and pulse pressure changes, allowing for venous pressure assessment.
- Reserpine demonstrates a normalizing effect on venous tone in hypertensive patients, suggesting its therapeutic potential.
Abstract:
Peripheral venous tone was measured in 124 patients with essential hypertension and in 20 healthy persons by digital electroplethysmography according to B. E. Votchal. In patients with hypertension stage II, the venous tone significantly decreased with increasing arterial tone; in patients in stage I this tendency was statistically not significant. In orthostasis the increase in venous tone was much lesser than that in arterial tone. The close positive correlation between venous capacity and the degree of decrease in systolic and pulse pressure make it possible to assess the systemic venous pressure on the basis of findings obtained from occlusion plethysmographic measurements. In patients with hypertensive disease in stage IIA, treated with reserpine, the arterial tone and pressure decreased, whereas the venous tone significantly increased (normalized).