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Related Experiment Videos

Codeine, cough and upper respiratory infection

R Eccles1

  • 1Common Cold Centre, School of Molecular and Biomedical Sciences, University of Wales, Cardiff, UK.

Pulmonary Pharmacology
|October 1, 1996
PubMed
Summary
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Codeine may not effectively treat coughs from upper respiratory tract infections (URTIs). New research suggests codeine only inhibits reflex cough, not voluntary cough pathways associated with URTIs.

Area of Science:

  • Pharmacology
  • Respiratory Medicine
  • Clinical Investigation

Background:

  • Codeine is a reference antitussive, but its efficacy for cough due to upper respiratory tract infection (URTI) is poorly studied.
  • Limited evidence supports codeine's effectiveness in URTI-associated cough models.
  • Existing literature shows codeine's antitussive effects in animal models and for induced/chronic cough in humans.

Purpose of the Study:

  • To investigate the antitussive efficacy of codeine in cough associated with URTI.
  • To explore the potential mechanisms behind codeine's variable effects on different cough models.
  • To propose a hypothesis explaining codeine's differential impact on cough pathways.

Main Methods:

  • Review of the mechanism of cough in humans.

Related Experiment Videos

  • Description of clinical investigations on codeine's effects on URTI-associated cough.
  • Analysis of existing literature on codeine's antitussive activity in various models.

    • Main Results:

    • Recent clinical investigations found no evidence supporting codeine's antitussive action in URTI-associated cough.
    • Literature indicates codeine inhibits fictive cough in animal models.
    • Codeine demonstrates antitussive activity in induced and chronic cough models in humans.

    Conclusions:

    • A hypothesis suggests two distinct cough pathways in humans: a voluntary pathway for URTI cough unaffected by codeine, and a reflex pathway for induced/chronic cough inhibited by codeine.
    • Codeine's efficacy may be pathway-dependent, explaining its variable effects.
    • Further research is needed to validate the two-pathway hypothesis and its clinical implications for antitussive therapy.