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Updated: Sep 13, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
Calmodulin-regulated adenylyl cyclases and neuromodulation
1Department of Environmental Health and Toxicology, University of Washington School of Public Health, Seattle, Washington 98195, USA. zxia@dehpost.sphcm.washington.edu
Abstract:
Coincidence detection and crosstalk between signal transduction systems play very important regulatory roles in the nervous system, particularly in the regulation of transcription. Coupling of the Ca2+ and cAMP regulatory systems by calmodulin-regulated adenylyl cyclases is hypothesized to be important for some forms of synaptic plasticity, neuroendocrine function, and olfactory detection. Recent studies of a mutant mouse deficient in type I calmodulin-sensitive adenylyl cyclase have provided the first evidence that adenylyl cyclases are important for synaptic plasticity, as well as for learning and memory in vertebrates.
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