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[Brain functional MRI using 3D-SPGR pulse sequence]

Y Watanabe1, T Nishimura

  • 1Department of Radiology, National Toneyama Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|July 1, 1997
PubMed
Summary
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This study used conventional magnetic resonance imaging (MRI) to observe brain activity during motor cortex stimulation. Increased signal intensity in the sensorimotor cortex indicates blood oxygenation level dependent (BOLD) effects during finger-thumb touching tasks.

Area of Science:

  • Neuroimaging
  • Functional Magnetic Resonance Imaging (fMRI)
  • Neurophysiology

Context:

  • Conventional 1.5 T clinical MRI scanners are widely available.
  • Motor cortex activity can be non-invasively studied.
  • Blood oxygenation level dependent (BOLD) effects are a key indicator of neural activity.

Purpose:

  • To investigate the effects of motor cortex stimulation using conventional MRI techniques.
  • To evaluate the utility of 2D and 3D spoiled gradient recalled echo (SPGR) sequences for detecting BOLD signals.
  • To demonstrate BOLD-based functional imaging in normal volunteers.

Summary:

  • Normal volunteers underwent motor cortex stimulation via sequential finger-to-thumb touching.
  • Optimized 2D and 3D SPGR sequences were employed on a 1.5 T MRI scanner.

Related Experiment Videos

  • Increased signal intensity was observed in the sensorimotor cortex, primarily attributed to BOLD effects with the 3D-SPGR method.

    • Impact:

    • Conventional MRI techniques can successfully detect functional brain activation.
    • The 3D-SPGR sequence is effective for BOLD-based fMRI, being less susceptible to inflow effects.
    • This study validates a non-invasive method for mapping sensorimotor cortex activity.