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[Assessment of regional microcirculatory changes by EPI perfusion studies in patients with multiple lacunar
M Ishihara1, Y Amano, S Kumita
1Department of Radiology, Main Hospital, Nippon Medical School.
Abstract:
The aim of this report is to assess regional cerebral microcirculatory changes by EPI perfusion study in patients with multiple lacunar infarction(MLI). Especially, we focused on the parameter(rCBV, MTT, rCBF) changes in the white matter and on the relationship between these changes in the gray and white matter. Twenty MLI patients(mean age 72 +/- 15 years) and 10 age-similar normal controls (mean age 65 +/- 12 years) were examined. As a result, the MLI patients demonstrated an insignificant rCBF reduction due to the rCBV elevation in the gray matter and a moderate rCBF reduction with less rCBV elevation in the white matter. These results show a difference in the vascular reserve between the gray and white matter, and insufficiency of the vascular reserve in MLI's white matter.
Insights
Multiple lacunar infarction (MLI) patients show reduced white matter vascular reserve. Cerebral blood flow (CBF) is reduced, particularly in white matter, indicating microcirculatory changes in MLI.
Area of Science:
- Neurology
- Neuroimaging
- Cerebrovascular Diseases