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Extensive genetic diversity in Blastocystis hominis
1Department of Medical Parasitology, London School of Hygiene and Tropical Medicine, UK. g.clark@lshtm.ac.uk
Molecular and Biochemical Parasitology
|July 1, 1997
Summary
Blastocystis hominis, a common human parasite, exhibits significant genetic diversity. This genetic variation may explain why its role in human disease remains debated, necessitating consideration in future research.
Area of Science:
- Medical Parasitology
- Molecular Biology
- Human Microbiome Research
Background:
- Blastocystis hominis is a prevalent human intestinal parasite with an unclear pathogenic role.
- Conflicting reports exist regarding its implication versus exoneration as a disease-causing agent.
Purpose of the Study:
- To investigate the genetic diversity within Blastocystis hominis isolates.
- To explore the potential link between genetic variation and pathogenicity.
Main Methods:
- Riboprinting technique was employed to analyze sequence variations.
- Small subunit ribosomal RNA (SSrRNA) genes from 30 B. hominis isolates were sequenced.
Main Results:
- Extensive sequence variation was identified in the SSrRNA genes of B. hominis.
- At least seven distinct genetic variants, morphologically identical, were discovered.
- This genetic heterogeneity suggests B. hominis is not a single entity.
Conclusions:
- The observed genetic diversity of Blastocystis hominis may explain the contradictory clinical findings.
- Future studies on B. hominis pathogenicity must account for its significant genetic heterogeneity.