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Related Experiment Videos

Diterpenes from coffee beans decrease serum levels of lipoprotein(a) in humans: results from four randomised

R Urgert1, M P Weusten-van der Wouw, R Hovenier

  • 1Agricultural University, Department of Human Nutrition, Wageningen, The Netherlands.

European Journal of Clinical Nutrition
|July 1, 1997
PubMed
Summary

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Coffee diterpenes, like cafestol and kahweol, can lower lipoprotein(a) levels. However, this effect may diminish over time, and side effects limit their use.

Area of Science:

  • Cardiovascular Research
  • Nutritional Science
  • Lipid Metabolism

Background:

  • Unfiltered coffee contains diterpenes (cafestol and kahweol) known to elevate LDL cholesterol.
  • Elevated serum lipoprotein(a) [Lp(a)], an LDL-like particle, is common in Norwegians with high unfiltered coffee intake and is resistant to dietary changes.
  • The influence of coffee diterpenes on Lp(a) levels requires experimental investigation.

Purpose of the Study:

  • To experimentally investigate the effect of coffee diterpenes on serum lipoprotein(a) levels.
  • To determine if cafestol and kahweol can modulate Lp(a) concentrations in humans.

Main Methods:

  • Four randomized controlled trials were conducted.
  • Participants included healthy volunteers with normal lipid levels.

Related Experiment Videos

  • Interventions involved consumption of coffee, coffee oil, or pure diterpenes for 4-24 weeks.
  • The primary outcome measured was the circulating level of lipoprotein(a).

    • Main Results:

    • Consumption of unfiltered coffee (cafetiere) led to a significant reduction in Lp(a) levels after two months.
    • Doses of coffee oil equivalent to 10-20 cups of unfiltered coffee reduced Lp(a) by up to 5.5 mg/dL.
    • Purified cafestol and kahweol mixtures, and cafestol alone, also effectively decreased Lp(a) levels.
    • On average, 10 mg/day of cafestol (plus kahweol) decreased Lp(a) by 4% from baseline after four weeks.

    Conclusions:

    • Coffee diterpenes are among the few dietary components demonstrated to influence serum Lp(a) levels.
    • The Lp(a)-reducing efficacy of coffee diterpenes may decrease with prolonged intake.
    • Adverse side effects associated with coffee diterpenes prevent their therapeutic application for lowering Lp(a).