Related Experiment Videos
Use of polyetherurethane to improve the biocompatibility of vascular stents
A B Fontaine1, S Dos Passos, D Spigos
1Division of Vascular and Interventional Radiology, Ohio State University Hospitals, Columbus, USA.
Purpose:
To investigate potential differential growth on neointima following overdilating arterial trauma with polyetherurethane-coated versus bare metallic stents in swine.
Methods:
Twelve specially constructed tantalum stents, 6 coated with polyetherurethane block copolymer and 6 uncoated, were overdilated by 25% in 12 normal renal arteries of six swine. The stents were harvested 8 weeks after implantation and prepared for histologic examination. Neointimal thickness was quantified and analyzed for significant differences between coated and uncoated prostheses.
Results:
All specimens demonstrated fractures of the internal elastic lamina consistent with vascular injury. There was significantly less neointimal formation (0.0001 < p < 0.05) in coated specimens as compared to uncoated controls in each test animal.
Conclusions:
The vascular response to overdilating stent trauma appears to be moderated with the use of polyetherurethane block copolymer as compared to control.