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Diagnosis of viral hepatitis with a nonisotopic hybridization assay

E Cariani1, A Ravaggi, A Zonaro

  • 1Consorzio per le Biotecnologie, Consiglio Nazionale delle Ricerche (CNR), Brescia, Italy.

Nuclear Medicine and Biology
|April 1, 1994
PubMed

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In-situ Hybridization02:31

In-situ Hybridization

In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...