[Neurologic signs in Addison-Biermer disease (report of 3 cases)]

The authors report three patients in whom a neurological syndrome was the first manifestation of Addison-Biermer disease. In the first case a paraneoplastic neurological syndrome was suspected, in two other cases the initial tentative diagnosis was multiple sclerosis. The correct diagnosis was reached after a prolonged diagnostic procedure and after ruling out of other diseases. The course of the disease was very serious in all cases leading to death of one patient despite intensive treatment (postmortem examination confirmed the diagnosis). In the second case the neurological syndrome failed to regress completely. The authors stress the necessity of considering this aetiology in neurological syndromes of atypical pattern and course.